منابع مشابه
Tumour Antigens Recognized by Antibodies
Considerable progress has been made in the last few decades in the identification of defined tumour-associated antigens recognized by monoclonal antibodies (mAbs). The generation of mAbs against tumour antigens has principally been through standard hybridoma techniques following immunization of mice, while in the last decade recombinant phage display technology has also been employed. Much of t...
متن کاملRetroviral targeting to tumour antigens
The development of efficient, cell surface targeted retroviral vectors is critical for successful gene therapy as gene delivery to non-target cells may be harmful and would deplete the pool of viral particles. To date, the only surface-targeting strategies that have allowed efficient infection by retroviral vectors in vivo are those that have limited the tropism of amphotropic murine leukaemia ...
متن کاملClinical value of tumour-associated antigens.
Since the first clear demonstration of the existence of 'specific' antigens in experimental tumours (Gross, 1943; Foley, 1953), the extensive use of syngeneic animals has resulted in the identification of tumour-associated or characteristic macromolecules ('antigens') in association with spontaneously occurring or experimentally induced tumours (Old and Boyse, 1964; Baldwin, 1970; Stonehill and...
متن کاملSpecificity of tumour associated transplantation antigens (TATA) of different clones from the same tumour.
The TATA of two clones from the same murine methylcholanthrene-induced fibrosarcoma have been investigated by immunizing syngeneic mice with irradiated cells of one or both clones and challenging them 14 days later with viable cells. The tumour had been induced in a female backcross CBA mouse heterozygous for the A and B alloenzymes of phosphoglycerate kinase-1 (PGK-1). One clone expressed A an...
متن کاملHuman tumour-associated and tumour-specific antigens: some concepts in relation to clinical oncology.
The concept of tumour-specific antigens is constantly undergoing reappraisal with the development of more sensitive methods for their detection. This has resulted in the finding that the many 'new' antigens produced by human tumours or materials immunologically closely related to them are also present in non-neoplastic tissues, albeit in small amounts. However, other antigens still appear to ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/271211a0